Uncontrolled HIV Load May Increase Risk of Non-Hodgkin Lymphoma
Use of highly active antiretroviral therapy (HAART) for at least 6 months appears to reduce the risk of non-Hodgkin lymphoma (NHL), but uncontrolled viral load increases the risk, AIDS investigators in France report.
Dr. Fabrice Bonnet of Hopital Saint-Andre in Bordeaux and associates conducted a case-control study of 55 patients with AIDS-related B-cell NHL and 145 controls matched for CD4+ cell count, sex, length of follow-up and calendar period. All of the subjects enrolled in Aquitaine Cohort study.
Dr. Bonnet and colleagues' objective was to determine what variables decreased risk of NHL, the most common AIDS-related neoplasia and a leading case of AIDS mortality.
The odds ratio (OR) for neoplasia among patients with at least 6 months of HAART was 0.46 and an undetectable HIV RNA level during follow-up carried an OR of 0.34. In addition to HAART, the use of antiherpetic medication decreased the risk of NHL, with an odds ratio of 0.40.
Age, transmission group, co-infection with hepatitis B or C, peak levels of CD4+ and CD8+ and a history of herpes virus infection were not associated with NHL risk, according to the report, published in the February 1st issue of Clinical Infectious Diseases.
Dr. Bonnet comments that the study "confirms that a minimum duration of 6 months of HAART is required to prevent NHL" and that HIV RNA level "is a possible risk factor for AIDS-related NHL in the era of HAART, independent of immunodeficiency."
Dr. Fabrice Bonnet of Hopital Saint-Andre in Bordeaux and associates conducted a case-control study of 55 patients with AIDS-related B-cell NHL and 145 controls matched for CD4+ cell count, sex, length of follow-up and calendar period. All of the subjects enrolled in Aquitaine Cohort study.
Dr. Bonnet and colleagues' objective was to determine what variables decreased risk of NHL, the most common AIDS-related neoplasia and a leading case of AIDS mortality.
The odds ratio (OR) for neoplasia among patients with at least 6 months of HAART was 0.46 and an undetectable HIV RNA level during follow-up carried an OR of 0.34. In addition to HAART, the use of antiherpetic medication decreased the risk of NHL, with an odds ratio of 0.40.
Age, transmission group, co-infection with hepatitis B or C, peak levels of CD4+ and CD8+ and a history of herpes virus infection were not associated with NHL risk, according to the report, published in the February 1st issue of Clinical Infectious Diseases.
Dr. Bonnet comments that the study "confirms that a minimum duration of 6 months of HAART is required to prevent NHL" and that HIV RNA level "is a possible risk factor for AIDS-related NHL in the era of HAART, independent of immunodeficiency."
posted by TM at 8:06 AM
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